Placenta-on-a-Chip developed by NIH

The Placenta-on-a-Chip has been developed, by National Institute of Health researchers and their colleagues, to study the inner workings of the human placenta.

The device was designed to imitate, on a micro-level, the structure and function of the placenta and model the transfer of nutrients from mother to fetus. This prototype is one of the latest in a series of organ-on-a-chip technologies developed to accelerate biomedical advances.

The study, published online in The Journal of Maternal-Fetal & Neonatal Medicine, was conducted by an interdisciplinary team of researchers from the NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and their colleagues.

Dr. Romero, Chief of the Perinatology Research Branch of the Division of Intramural Research of NICHD, said: “We believe that this system may be used to address questions which are difficult to answer with the current placenta model systems and serve to enable research in pregnancy and its complications.”

The placenta is a temporary organ that develops in pregnancy and is the major interface between mother and fetus. One of its many functions is to serve as a “crossing guard” for substances traveling between mother and fetus. The placenta helps nutrients and oxygen move to the fetus and helps waste products move away. At the same time, the placenta tries to stop harmful environmental exposures, like bacteria, viruses and certain medications, from reaching the fetus. When the placenta doesn’t function correctly, the health of both mom and baby suffers.

Researchers are trying to learn how the placenta manages to transport some substances and block others. This knowledge may one day help clinicians better assess placental health and ultimately improve pregnancy outcome.

However, studying the placenta in humans is challenging: it’s time-consuming, subject to a great deal of variability, and potentially risky for the fetus. For those reasons, previous studies on placental transport have relied in large on animal models and on laboratory-grown human cells. These methods have yielded helpful information, but are limited as to how well they can mimic physiological processes in humans.

The researchers created the Placenta-on-a-Chip technology to address these challenges, using human cells in a structure that more closely resembles the placenta’s maternal-fetal barrier. The device consists of a semi-permeable membrane between two tiny chambers, one filled with maternal cells derived from a delivered placenta and the other filled with fetal cells derived from an umbilical cord.

After designing the structure of the model, the researchers tested its function by evaluating the transfer of glucose from the maternal compartment to the fetal compartment. The successful transfer of glucose in the device mirrored what occurs in the body.

Dr. Romero said: “The chip may allow us to do experiments more efficiently and at a lower cost than animal studies. With further improvements, we hope this technology may lead to better understanding of normal placental processes and placental disorders.”