New optical devices speed up disease diagnosis

Two new optical devices, the multiphoton microscope and endoscope, could speed up disease diagnosis by reducing the need to take tissue samples for testing during medical examinations and operations

One device is a lightweight handheld microscope designed to examine external tissue or tissue exposed during surgery. It could be used to help surgeons compare normal and cancerous cells (during an operation), according to Imperial College London (ICL).

The device can acquire 3D images of parts of the body while patients are moving (eg due to normal breathing), enabling it to be applied to almost any exposed area of a patient’s body.

The second instrument, an endoscope incorporating optical fibres and control of the light coupled into it, has the potential to be inserted into the body to carry out internal cell-scale examination, for example during neurosurgery.

Ultimately, ICL said that this new approach may be able to provide high resolution images enabling surgeons to see inside individual cells at an adjustable depth beneath the surface of the tissue.

Both prototypes have been developed by ICL in collaboration with the University of Bath and funded by the Engineering and Physical Sciences Research Council (EPSRC). 

Currently, the diagnosis of many diseases requires taking a tissue specimen from the patient, preparing it in a laboratory, studying it under a microscope and then forwarding the results back to the clinician.

The new devices, both of which harness a technique known as multiphoton excited fluorescence microscopy to analyse individual cells in their native tissue, could be used in a consulting room or an operating theatre to help clinicians identify diseased tissue and provide a rapid diagnosis, according to ICL.

Both these devices use novel multicore optical fibres developed by Imperial’s collaborators by the University of Bath.

Chris Dunsby of Imperial College London, who has led the overall project, said: “These new devices open up exciting possibilities in the field of in-situ diagnosis and could help improve patient care in the future.”

Jonathan Knight, who led the University of Bath team, said: “This has been a very exciting project which has enabled us to develop fibres with performance which we would have previously thought impossible.”

After further development and refinement of the technology, clinical trials will explore the healthcare benefits of the two devices in more detail, with the goal of beginning to introduce them into clinical use within around 5-10 years, according to ICL.