Renishaw has built a device used in a clinical trial that allows the delivery of Glial Cell Line Derived Neurotrophic Factor (GDNF) with the hope of regenerating dying dopamine brain cells in people with Parkinson’s.
The device was manufactured on behalf of Bristol NHS Trust and hopes to improve the symptoms of patients.
Renishaw worked with consultant neurosurgeon, Professor Steven Gill, to manufacture the drug delivery system, which bypasses the blood-brain barrier.
During the trial, 42 patients had the additively manufactured titanium port embedded into their skull through which GDNF could be delivered via micro-catheters to the putamen, a critical region of the brain for motor function. The device is implanted using the Renishaw neuromate surgical robot, which positions four catheters into the brain.
Professor Steven Gill, said: “This trial has shown that we can safely and repeatedly infuse drugs directly into patient's brains over months or years through a small implanted port that emerges through the skin behind the ear. This is a significant breakthrough in our ability to treat neurological conditions, such as Parkinson's because most drugs that might work cannot cross from the bloodstream into the brain due to a natural protective barrier.
“Even at a low dose we have seen evidence of patient improvement, which is incredibly encouraging. Now we need to move towards a definitive clinical trial using higher doses and this work urgently needs funding. I believe that this approach could be the first neuro-restorative treatment for people living with Parkinson's which is, of course, an extremely exciting prospect.”
The trial was funded by Parkinson's UK with support from the Cure Parkinson's Trust and in association with the North Bristol NHS Trust. Results announced on February 27th showed that the drug delivery system performed effectively and reliably and a similar device, developed by Renishaw called ‘neuroinfuse', is now being used in other clinical trials.
Paul Skinner, general manager for neurological products at Renishaw, said: “It has been a privilege to work alongside the study team and with the participants in this ambitious trial. We are very encouraged that there were changes in the brain scans, demonstrating that GDNF is having an effect, and that the delivery system achieved precision administration of drugs into the brain.
“This provides great potential for using the drug delivery system, being developed by Renishaw, for future Parkinson's studies and experimental treatments for other neurodegenerative diseases and brain tumours.”